Same same but different: FCD IIb vs. TSC – distinct histomorphological features revealed with the help of deep learning

Malformations of Cortical Development (MCD) are a heterogenous group of disorders that are a common cause of various degrees of neurodevelopmental delay and refractory epilepsy. Focal cortical dysplasia type IIb (FCD IIb) and tuberous sclerosis complex (TSC) are two classes of MCD, with balloon cells as a pathognomonic feature of both FCD IIb and TSC. Currently it is impossible for a neuropathologist to distinguish balloon cells of both entities in hematoxylin–eosin stain (H&E) using brightfield microscopy, so matching the clinical data with histomorphological results & genetic testing is obligatory for a precise diagnosis.

Joshua Kubach is currently working on this project and we are close to submission…

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